Metallic salts of methylene disalicylic acid and process of making same.



UNITED STATES PATENT OFFICE.

SAMUEL LEWIS SUMMERS, OF PHILADELPHIA, PENNSYLVANIA.

METALLIC SALTS OF METHYLENE DISALICYLIC ACID AND PROCESS OF MAKING SAME.

SPECIFICATION forming part of Letters Patent No. 716,593, dated December23, 1902.

Application filed June 16,1902. Serial No. 111,935. (No specimens.)

To aZZ whom it may concern.-

Be it known that I, SAMUEL LEWIS SUM- MERS, a citizen of the UnitedStates, residing in the city of Philadelphia, State of Pennsylvania,have invented and discovered certain new and useful Metallic Salts ofMethylene Disalicylic Acid and Process of Producing the Same, of whichthe following is a full, clear, and exact description.

My invention relates to a new chemical compound having especial utilityas a pharmaceutical product by reason of its therapeutic value,particularly as an internallyadministered antiseptic ingastro-intestinal diseases, wherein doses of from two to five grainsproduce marked beneficial results, and I believe it will be found usefulin other cases as the result of further clinical tests.

The new bodyis genericallya metallic salt of methylene disalicylic acid,in which the base is of the class known as heavy metals.

In a former application for Letters Patent filed by me April 24, 1902,Serial No. 104, 821, I have described and claimed an acid body namely,methylene disalicylic acid-which will be found fully described in thespecification attached to said application and which therefore need notbe further described herein, save to say that it is a crystalline bodycomposed of two salicylic-acid molecules deprived of one hydrogen atomin each salicylic-acid group and chemically united or held together bythe methylene group. In another application bearing even date herewith Ihave described and claimed the prodnot and process of making the alkalisalts of this body and which being fully described therein need not behere repeated, save to say generally that it consists in taking asoluble compound of one of the alkalies such as sodium, ammonium,lithium, and potassium-and allowing it to react on methylene disalicylicacid. I produce an alkali salt thereof, which may be described as havingthe formula C, H O (R) in which R represents the alkali metal.

My presentinvention consists in taking the last-named body as a startingmaterial and allowing a soluble salt of one of the heavy metals, ashereinafter stated, to react thereon in the manner and proportionsdescribed. I produce another new body having valuable medicinalproperties namely, methylene disalicylic acidin and with which the heavymetal of the salt employed in the reaction is chemically united. Forexample, desiring to produce the bismuth salt from the sodium methylenedisalicylate referred to I take three hundred and thirty-two parts ofthe latter dissolved in five thousand parts of water and add thereto afifty-per-cent.-acetic-acid solution of two hundred and eighty parts ofpure bismuth nitrate, whereupon a precipitate is formed, which is to bewashed free from soluble salts, giving a powder which is white andhaving the formula (C,,H, O (CO Bi insoluble in alcohol and ether. Ananalogous reaction takes place if an aqueous solution of one hundred andtwelve parts of ferric chlorid, or one hundred and twenty parts of purealuminium sulfate, or two hundred and ninety-five parts of purecrystallized zinc sulfate, or one hundred and ninety parts of purecadmium chlorid, or one hundred and ninety-five parts of pure coppernitrate are substituted for the acetic-acid solution of bismuth nitrate,the resulting specific metallic salt of the body acted on in each casebeing produced by the same general reaction and having the same generalcharacteristics, differing, of course, somewhat in color of the endproduct, the greater or less insolubility in ether and alcohol, and thespecific metal, but all of the species being insoluble in water eitherhot or cold.

Having thus described my invention, what I claim as new, and desire tosecure by Letters Patent, is-

l. The new product described, which is a metallic salt of methylenedisalicylic acid, wherein a heavy metal is chemically united with theacid residue of methylene disalicylic acid; an impalpable powder, havinga color governed by the specific metallic salt employed; more or lessinsoluble in ether and alcohol; insoluble in water, either hot or cold;and having the chemical constitution hereinabove recited.

2. The process described, of producing the In testimony whereof I havehereunto afmetallic salts of methylene disalicylic acid, fixed mysignature this 9th day of June, A. D. which consists in allowing asolution of the 1902.

salts of a heavy metal to react on an alkali SAMUEL LEWIS SUMMERS.

salt of methylene disalicylic acid in aqueous Witnesses: solution, andisolating the resultant precipi- WAYNE P. RAMBO,

- PHINEAS RAMBO.

tate.

